द्विषोऽमित्रे

Operational rule vidhi

The affix शतृ comes after the verb द्विष् when the agent indicated means 'an enemy'.

Word by word (padaccheda)

Left context द्विषः pañcamī · ekavacanaRight context अमित्रे saptamī · ekavacana

Left context Pañcamī (5th case): "after X", the operation applies to what follows (1.1.67 तस्मादित्युत्तरस्य). Also used for limits and sources.
Right context Saptamī (7th case): "when X follows", the operation applies to what precedes (1.1.66 तस्मिन्निति निर्दिष्टे पूर्वस्य). Also a condition or domain ("in the sense of").

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Full reading

द्विषः अमित्रे

Pāṇini leaves out words that carry over from earlier sūtras. Expand to see the rule as a reader actually understands it.

Commentary

The affix शतृ comes after the verb द्विष् when the agent indicated means 'an enemy'.
The word अमित्र means 'enemy'. As द्विषन् 'enemy', द्विषन्तौ 'two enemies', द्विषन्तः 'enemies'.

Why do we say 'when denoting an enemy'? Observe द्वेष्टि भार्या पतिम् 'the wife hates her husband'.

Śrīśa Chandra Vasu, The Ashtadhyayi of Panini (1897), via ashtadhyayi.com.