इङ्धार्योः शत्रकृच्छ्रिणि

Operational rule vidhi

The affix शतृ comes after the verb इङ् 'to go' and धारि 'to hold' in denoting that the agent does the action without trouble.

Word by word (padaccheda)

Target इङ्- धार्य्योः ṣaṣṭhī · dvivacanaWord शतृ Right context अकृच्छ्रिणि saptamī · ekavacana

Target Ṣaṣṭhī (6th case): names what gets replaced, "in place of X" (1.1.49 षष्ठी स्थानेयोगा).
Word Case not marked in the source data.
Right context Saptamī (7th case): "when X follows", the operation applies to what precedes (1.1.66 तस्मिन्निति निर्दिष्टे पूर्वस्य). Also a condition or domain ("in the sense of").

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Full reading

इङ्-धार्य्योः शतृ अकृच्छ्रिणि

Pāṇini leaves out words that carry over from earlier sūtras. Expand to see the rule as a reader actually understands it.

Commentary

The affix शतृ comes after the verb इङ् 'to go' and धारि 'to hold' in denoting that the agent does the action without trouble.
The word अकृच्छ्र means that which is accomplished by the agent with ease and facility. As अधीयन् पारायणम् 'the facile reading of the Purana'; धारयन्नुपनिषदम् 'easily mastering the Upanishad'. The root धारि is causative of धृ and means here 'to master'.

Why do we say 'when facility is indicated'? Otherwise कृच्छ्रेणाधीते 'he reads with difficulty'; कृच्छ्रेण धारयति 'he remembers with difficulty'.

Śrīśa Chandra Vasu, The Ashtadhyayi of Panini (1897), via ashtadhyayi.com.