व्यञ्जनैरुपसिक्ते

Operational rule vidhi

The affix ठक् comes after a word denoting a condiment, being in the Instrumental -3rd case in construction when the sense is 'sprinkled therewith'.

Word by word (padaccheda)

With / by व्यञ्जनैः tṛtīyā · bahuvacanaRight context उपसिक्ते saptamī · ekavacana

With / by Tṛtīyā (3rd case): accompaniment or means.
Right context Saptamī (7th case): "when X follows", the operation applies to what precedes (1.1.66 तस्मिन्निति निर्दिष्टे पूर्वस्य). Also a condition or domain ("in the sense of").

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Full reading

व्यञ्जनैः उपसिक्ते

Pāṇini leaves out words that carry over from earlier sūtras. Expand to see the rule as a reader actually understands it.

Commentary

The affix ठक् comes after a word denoting a condiment, being in the Instrumental -3rd case in construction when the sense is 'sprinkled therewith'.
Thus दध्ना उपसिक्तं = दाधिकम् 'sprinkled with curd', सौपिकम्, खारिकम् ॥ Why do we say 'denoting a condiment'? Observe उदकेनोपसिक्तं ओदनः ॥

Śrīśa Chandra Vasu, The Ashtadhyayi of Panini (1897), via ashtadhyayi.com.