कोपधाच्च

Operational rule vidhi

After a word having क् as its penultimate, the affix अण् comes in the sense of modification or a part or both, as appropriate.

Word by word (padaccheda)

Left context क- pañcamī · ekavacanaIndeclinable च avyaya

Left context Pañcamī (5th case): "after X", the operation applies to what follows (1.1.67 तस्मादित्युत्तरस्य). Also used for limits and sources.
Indeclinable An avyaya such as च "and", वा "optionally", न "not".

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Full reading

क- च

Pāṇini leaves out words that carry over from earlier sūtras. Expand to see the rule as a reader actually understands it.

Commentary

After a word having क् as its penultimate, the affix अण् comes in the sense of modification or a part or both, as appropriate.
This debars अञ्. Thus; तर्कु तार्क्कवम्, तित्तिडीक, तैत्तिडीकं; माण्डूकम्, दार्दुरूकम् माधूकम् ॥ The word तित्तिडीक &c have acute on the middle (Phit Su. II.16).

Śrīśa Chandra Vasu, The Ashtadhyayi of Panini (1897), via ashtadhyayi.com.