ददातिदधात्योर्विभाषा

Operational rule vidhi

The affix श is optionally used after the root दा 'to give' and धा 'to hold', when used without a preposition.

Word by word (padaccheda)

Left context ददाति- दधात्योः pañcamī · dvivacanaSubstitute / term prathamā · ekavacana

Left context Pañcamī (5th case): "after X", the operation applies to what follows (1.1.67 तस्मादित्युत्तरस्य). Also used for limits and sources.
Substitute / term Prathamā (1st case): in operational rules, the substitute or the thing introduced; in definitions, the term or its referent.

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Full reading

ददाति-दधात्योः

Pāṇini leaves out words that carry over from earlier sūtras. Expand to see the rule as a reader actually understands it.

Commentary

The affix श is optionally used after the root दा 'to give' and धा 'to hold', when used without a preposition.
This debars ण. Thus ददः 'giving'; or दायः 'inheritance'; दधः 'holding' or धायः 'having'.

When a preposition is used, the affix श is not employed; as प्रदः, प्रधः.

Śrīśa Chandra Vasu, The Ashtadhyayi of Panini (1897), via ashtadhyayi.com.