दूरान्तिकार्थेभ्यो द्वितीया च

Operational rule vidhi

After the words दूर 'distant' and अन्तिक 'near', the 2nd case-affix is used as well as the 5th and the 3rd.

Word by word (padaccheda)

Left context दूर- अन्तिक- अर्थेभ्यः pañcamī · bahuvacanaSubstitute / term द्वितीया prathamā · ekavacanaIndeclinable च avyaya

Left context Pañcamī (5th case): "after X", the operation applies to what follows (1.1.67 तस्मादित्युत्तरस्य). Also used for limits and sources.
Substitute / term Prathamā (1st case): in operational rules, the substitute or the thing introduced; in definitions, the term or its referent.
Indeclinable An avyaya such as च "and", वा "optionally", न "not".

Full reading

दूर-अन्तिक-अर्थेभ्यः द्वितीया च

Pāṇini leaves out words that carry over from earlier sūtras. Expand to see the rule as a reader actually understands it.

Commentary

After the words दूर 'distant' and अन्तिक 'near', the 2nd case-affix is used as well as the 5th and the 3rd.
Ex. दूरं दूराद् दूरेण वा ग्रामस्य and अन्तिकात्, or अन्तिकेन अन्तिकं ग्रामस्य.

This rule applies only when these words have their original signification and do not denote a substance. Otherwise the proper case-affix should be employed, as दूरः पन्थाः, दूराय पथे देहि.

Śrīśa Chandra Vasu, The Ashtadhyayi of Panini (1897), via ashtadhyayi.com.