दश्च

Operational rule vidhi

द् or रु may optionally be substituted for the द् of a root, , before the personal ending सि (स्) when such द् stands at the end of a word.

Word by word (padaccheda)

Target दः ṣaṣṭhī · ekavacanaIndeclinable च avyaya

Target Ṣaṣṭhī (6th case): names what gets replaced, "in place of X" (1.1.49 षष्ठी स्थानेयोगा).
Indeclinable An avyaya such as च "and", वा "optionally", न "not".

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Full reading

दः च

Pāṇini leaves out words that carry over from earlier sūtras. Expand to see the rule as a reader actually understands it.

Commentary

द् or रु may optionally be substituted for the द् of a root, , before the personal ending सि (स्) when such द् stands at the end of a word.
Thus अभिनत् त्वम् or अभिनस् त्वम्, अच्छिनत् त्वम् or अच्छिनस् त्वम् ॥

Śrīśa Chandra Vasu, The Ashtadhyayi of Panini (1897), via ashtadhyayi.com.